Simutaneous Assaying of Paracetamol and Caffeine in Ankahuangmin Capsules by HPLC
- VernacularTitle:高效液相色谱法同时测定氨咖黄敏胶囊中对乙酰氨基酚和咖啡因的含量
- Author:
Ke GAI
- Publication Type:Journal Article
- Keywords:
HPLC;
Ankahuangmin capsules;
Paracetamol;
Caffeine;
Assaying
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish HPLC method for the simultaneous assaying of paracetamol and caffeine in ankahua_ngmin capsules.METHODS:The determination was performed on phenomenex luna C18 column under room temperature;the mobile phase consisted of methanol-water(24∶76) with a flow rate at 1.0ml/min,detecting wavelength at 215 nm and sensibility at 0.01AUFS.RESULTS:The linear ranges for paracetamol and caffeine were 50～250?g/ml(r=0.9 999) and 5.0～25?g/ml(r=0.9 999),respectively.The average recoveries were 100.7%(RSD=1.8%)and 101.4%(RSD=1.4%),respectively.CONCLUSION:This method is simple,rapid and accurate,which can substitute for titration in the assaying of ankahua_ngmin capsules.
