Study on curative effect of Guben Fangchuan capsule (固本防喘胶囊) in treatment of patients with chronic obstructive pulmonary disease in acute exacerbating stage
- VernacularTitle:固本防喘胶囊对慢性阻塞性肺疾病急性加重期患者治疗作用的研究
- Author:
Weiqing LI
;
Xinqiao KE
;
Jinsong SUN
;
Wensheng LIAO
;
Shiwei CHEN
;
Qingshun HU
- Publication Type:Journal Article
- Keywords:
chymase;
interleukin-8;
eotaxin;
chronic obstructive pulmonary disease;
mast cell;
Guben Fangchuan capsule
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the mechanism of curative effects of Guben Fangchuan capsule (固本防喘胶囊) on chronic obstructive pulmonary disease(COPD). Methods: Using double blind control method , 86 elderly COPD patients in in acute exacerbating stage were divided into treatment group and control group (n=43 in each group). The conventional treatment of the two groups was the same. Additionally, the patients in the treatment group were given Guben Fangchuan capsules orally. The levels of interleukinCD*28 (ILCD*28) and eotaxin in phlegm were detected by enzyme linked immunoadsorbent assay (ELISA). Chymase activity in phlegm was determined by spectrophotometry. They were compared before and after treatment. Results: ①The activity of chymase, the levels of ILCD*28, eotaxin, neutrophil (NEU) and eosinophil (EOS) in phlegm in patients with intermediate and severe COPD patients were lower after treatment in treatment group than those of the patients before treatment and control group (all P
