Effects of Xuebijing injection (血必净注射液) on hemodynamics of dogs with endotoxic shock
- VernacularTitle:血必净注射液对内毒素休克狗血流动力学的影响
- Author:
Liehua DENG
;
Huaguo YAO
;
Yiming SHAO
- Publication Type:Journal Article
- Keywords:
endotoxic shock;
Xuebijing injection;
hemodynamics;
inflammatory mediators
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the influence of Xuebijing injection (血必净注射液) on hemodynamics of dogs with endotoxic shock and its mechanism. Methods: Endotoxic shock was induced by intravenous infusion of lipopolysaccharide of E.coli. O55:B5 to dogs, and the 24 dogs were randomly divided into control group and Xuebijing injection group. Xuebijing injection was administered in the Xuebijing injection group. The hemodynamic parameters and plasma lactate levels were monitored. Results: After the administration of endotoxin, the mean arterial pressure (MAP) decreased significantly, while the mean pulmonary artery pressure (MPAP) and cardiac index (CI) increased markedly in both groups (all P0.05). Moreover, plasma lactate level was lower in Xuebijing injection group than that in control group (P
