The relationship between vitamin D receptor gene TaqⅠ polymorphism and diabetic retinopathy
- VernacularTitle:维生素D受体Taq基因多态性与糖尿病视网膜病变的关系
- Author:
Jinghua SUN
;
Yanyan CHEN
;
Changming LIU
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy/genetics;
Receptors,calcitrol;
Locus control region;
Polymorphism,single nucleotide;
Polymerase chain reaction
- From:
Chinese Journal of Ocular Fundus Diseases
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the polymorphism of the vitamin D receptor gene (VDR)TaqⅠin relation to diabetic retinopathy. Method Fragment length discrepant allele specific PCR(FLDAS-PCR) were used to determine VDR genetypes in 158 patients with diabetic retinopathy and in 198 normal subjects. Results The frequency distribution of VDR genotypes in diabetic retinopathy patients was 106 (67.1%) in TT, 33(20.9%) in Tt, 19(12.0%) in tt; and in normal persons was 165 (83.3%) in TT, 23(11.6%) in Tt, 10 (5.1%) in tt. There was a significant difference between diabetic retinopathy patients and normal persons in distribution of VDR gene TaqⅠgenotypes(P
