Expression of collagen type Ⅰ, Ⅲ, MMP1, and TIMP1 in liver tissues of patients with chronic hepatitis B
- VernacularTitle:慢性乙型肝炎肝组织Ⅰ、Ⅲ型胶原及MMP1、TIMP1的表达
- Author:
Jingan LI
;
Xingfeng REN
;
Xiaokun WANG
;
Qun YANG
;
Jing YU
;
Ya GE
;
Ying TANG
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
Biopsy liver;
Type Ⅰ collagen protein;
Type Ⅲ collagen protein;
Matrix metalloproteinase1
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expressions of matrix metalloproteinase 1(MMP1) and tissue inhibitor of matrix metalloproteinase1(TIMP1) and the collagen type Ⅰ,Ⅲ deposition in the liver tissues,and evaluate the possible fibrosis mechanism of patients with chronic hepatitis B(CHB) in the way of degradation of collagen. Methods The specimens of the biopsy liver in 50 cases with CHB were detected for the expressions of type Ⅰ,Ⅲ collagen proteins,MMP1 and TIMP1 by immunohistochemical staining. Results The expressions of type Ⅰ,Ⅲ collagen proteins and TIMP1,were significantly increased along with the advancing of hepatic fibrosis.There was a positive correlation between the expressions of type Ⅰ,Ⅲ collagen proteins and TIMP1. Conclusions Hepatic fibrosis in the patients with CHB may be related to increase of TIMP1 expression that inhibit the degradation of collagen.
