A clinical study of perioperative coagulopathy treatment in patients undergoing liver transplantation
- VernacularTitle:肝移植患者术前的凝血治疗
- Author:
Dong WANG
;
Jiye ZHU
;
Pengji GAO
;
Fengxue ZHU
;
Guangming LI
;
Xisheng LENG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Blood coagulation;
Plasma exchange
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the timing, target and method for the treatment of preoperative coagulopathy in patients undergoing orthotopic liver transplantation. Methods We retrospectively assessed 168 adult patients undergoing orthotopic liver transplantation from 2002 to 2004. Preoperative prothrombin time(PT) , prothrombin activity (PTA) , international normalizing ratio(INR) , activated partial thromboplastin time(APTT) , fibrinogen (FIB) , and platelet count (PLT) were assessed. The relationship between PTA and intraoperative blood loss or use of blood product, preoperative plasma exchange and intraoperative blood loss or use of blood product were analysed. Results Preoperative normocoagulation significantly decreased intraoperative blood loss and blood product' s requirement. PTA level was in negative correlation with intraoperative blood loss and blood transfusion. Preoperative plasma exchange effectively reduced intraoperative bleeding and blood product's requirement. Conclusion Aggressive coagulatory therapy should be adopted to improve coagulation condition in order to reduce intraoperative blood loss and blood product's requirement.
