The effect of HO-1 activated via P38? pathway in the genesis and chemotherapy resistance of breast carcinoma
- VernacularTitle:经p38?通路激活的HO-1在乳腺癌发生和耐药中的作用
- Author:
Yingjiang YE
;
Shan WANG
;
Feifei YAN
;
Xueguang ZHU
;
Xinmin QIAO
;
Deqi YANG
;
Zhirong CUI
- Publication Type:Journal Article
- Keywords:
Breast neoplasm;
Heme oxygrnase(decyclizing);
Cell cycle;
Drug tolerance
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of p38? pathway and HO-1 in the genesis and chemotherapy resistance of breast cancer. Methods The proliferation and apoptosis of human breast cancer cells were examined by MTT assay. The expression of p38? and HO-1 mRNA were examined by RT-PCR. Results The p38? mRNA level in 78% of samples was significantly greater than that in the normal tissue and the p38? mRNA level in patients with lymph node metastasis was higher than that without lymph node metastasis (P
