In Vitro Antibacterial Activity of Meropenem and Its Pharmacokinetics in Patients with Burn Injury
- VernacularTitle:美洛培南的体外抗菌活性及其在烧伤患者体内的药动学研究
- Author:
Cai LIN
;
Songqing LIU
;
Qing DAI
;
Junying HE
- Publication Type:Journal Article
- Keywords:
Meropenem;
Minimal inhibitory concentration;
Pharmacokinetics;
Patients with burn injury
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the antibacterial activity of meropenem in vitro and the pharmacokinetics of which in patients with burn injury. METHODS: The minimal inhibition concentration (MIC) of meropenem against 136 clinical isolates was determined with double agar dilution method. 28 patients with burn injury were given 0.5g of meropenem by iv gtt, with the blood concentration of meropenem and the recovery of meropenem in urine were determined at different time. The pharmacokinetics parameters were computed with 3p97 software. RESULTS: Meropenem showed a strong antibacterial activity against K.peneumoniae, pneumonococcus and Enterobacter cloacae. MIC90 was below 0.0 075～0.25?g/ml. Pharmacokinetics parameters of meropenem were the following: t1/2? was (0.35?0.12) h,t1/2? was (2.10?0.71) h,AUC was (44.62?12.95) ?g/ml,Vc was (10.60?3.93) L; CLs was (12.00?3.04) L/h. 6.5 hours later, the mean blood concentration was (1.01?0.53)?g/ml; and the recovery of meropenem in 0h～12h urine was (58.06?16.83) %. CONCLUSIONS: Meropenem showed a very strong antibacterial activity in this study,there were significant differences regarding the in vivo pharmacokinetics parameters between the healthy volunteers and the patients with burn injury.
