Expressions of matrix metalloproteinases-2 and-9 in gallbladder carcinoma
- VernacularTitle:胆囊癌组织中MMP-2和MMP-9的表达及相关性研究
- Author:
Baoxiang ZHOU
;
Dexiang ZHU
;
Dianhua GU
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
Gallbladder neoplasms;
Matrix metalloproteinases-2;
Matrix metalloproteinases-9;
Imunohistochemistry
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the expression of MMP-2,MMP-9 and invasion of gallbladder carcinoma.Method Seventeen specimens of gallbladder carcinoma,9 cases of gallbladder adenoma and 9 cases of chronic cholecystis were assessed by using immunohistochemical method(S-P method).Results There were no significant difference in MMP-2 and MMP-9 expressions between gallbladder carcinoma and adenoma,but they were significantly higher than that of chronic cholecystis.The expressions of MMP-2 and MMP-9 had no correlation with the histological differentiation or Nevin staging.Conclusion MMP-2 and MMP-9 may play an important role in tumor invasion and metastasis in gallbladder carcinoma.
