Expression of ERK and MKP-1 in vascular smooth muscle of spontaneously hypertensive rats with different ages
- VernacularTitle:不同年龄高血压大鼠血管平滑肌中ERK和MKP-1的表达
- Author:
Zhong LIU
;
Shan LI
;
Jianhua ZHU
;
Chaoyang HUANG
- Publication Type:Journal Article
- Keywords:
Mitogen-activated protein kinases;
Hypertension;
Muscle, smooth, vascular;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of mitogen- activated protein kinase and mitogen-activated protein kinase phosphatase-1 in thoracic aorta smooth muscles of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) with different ages and the relationship between those and hypertension. METHODS: The caudal arterial pressure was measured by tail-cuff. Protein expression of p-ERK was detected by Western blotting, and MKP-1 mRNA in thoracic aorta smooth muscle was examined by RT-PCR. RESULTS: (1) The blood pressure of SHR was obviously higher than that of age-matched WKY (P
