Effect of fluvastatin on left ventricular remodeling and caspase-3 expression after myocardial infarction in rats
- VernacularTitle:氟伐他汀对大鼠心肌梗死后左室重构及caspase-3表达的影响
- Author:
Lan MA
;
Zhenzhong GUAN
;
Wei WU
- Publication Type:Journal Article
- Keywords:
Fluvastatin;
Ventricular remodeling;
Myocardial infarction Caspase-3
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of fluvastatin (FV) on left ventricular remodeling and expression of caspase-3 after myocardial infarction (MI) in rats. METHODS: Rats were divided into 4 groups: group Ⅰ (sham), group Ⅱ (sham+FV), group Ⅲ (MI) and group Ⅳ (MI+FV). group Ⅱ and Ⅳ were treated with FV (10 mg?kg -1?d -1) for 4 weeks. The left ventricular structure, echocardiography and hydroxyproline were observed. The expression of caspase-3 was measured by immunohistochemistry and RT-PCR. RESULTS: Compared with MI group, there was a improvement of ultrastructure and index of left ventricular remodeling, and decrease in hydroxyproline in MI+FV group (all P
