Experimental study on inhibition of restenosis by anti-osteopontin antibody after de-endothelium
- VernacularTitle:抗骨桥蛋白抗体抑制血管内膜增生的实验研究
- Author:
Mei HAN
;
Yonggang ZHANG
;
Jinkun WEN
- Publication Type:Journal Article
- Keywords:
Osteopontin;
Antibodies;
Tunica intima;
Hyperplasia
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the mechanism of inhibiting the neointimal formation through blocking osteopontin (OPN) by using anti-OPN antibody. METHODS: The anti-OPN antibody was injected via tail vein after the left carotid artery of rats was de-endothelialized by balloon catheter. The expression of matrix metalloproteinase-2 (MMP-2), tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) and OPN were detected by gelatin zymogram, Western blotting, immunohistochemistry and flow cytometry. RESULTS: The neointima in rats treated with anti-OPN antibody was significantly thinner than that in untreated rats (P
