Effects of heroin at different concentrations on electrophysiological properties of rat hippocampal CA1 pyramidal neurons
- VernacularTitle:不同浓度海洛因灌流对大鼠海马CA1区神经元电生理的影响
- Author:
Qunwan PAN
- Publication Type:Journal Article
- Keywords:
Heroin;
Hippocampus;
Electrophysiology
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate changes of electrophysiological properties of rat hippocampal CA1 pyramidal neurons in perfusion with heroin at different concentrations. METHODS: The intracellular recordings were made from CA1 pyramidal neurons of isolated hippocampal slices in perfusion with 0.03-0.3 mmol?L -1 heroin. Compared with control parametes before herion perfusion, the electrophysiological data obtained from identical neurons at 15 min after acute perfusion of the different concentration heroin were analyzed. RESULTS: With the increase of the heroin concentrations in perfusion, the absolute values of neuron resting potential and threshold potential decreased (P
