The methylation of p16 promotor in psoriatic keratinocytes
- VernacularTitle:银屑病角质形成细胞p16启动子甲基化的研究
- Author:
Yonghua XIA
;
Hongwen LI
;
Yi DING
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Genes, p16;
Methylation;
Promoter regions (genetics)
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the methylation of p16 promotor and the pathogenesis and progress of psoriasis. Method Methylation-specific PCR and DNA sequencing were used to detect the methylation of p16 promotor. Results The methylation of p16 promotor was found in 23.08% (6/26) of psoriatic lesions and 19.23% (5/26) of non-lesional areas in psoriatic patients, but none in normal controls. The frequency of methylation of p16 promotor was higher in psoriatic lesions than that in normal skin (P
