Expression of HINT/PKCI-1 mRNA in patients with malignant melanoma and nevus
- VernacularTitle:组氨酸三聚体核苷结合蛋白1mRNA在良恶性黑素细胞肿瘤中的表达
- Author:
Liuqing CHEN
;
Tong LIN
;
Xuesi ZENG
;
Jianfang SUN
- Publication Type:Journal Article
- Keywords:
Nevus;
Melanoma;
HINT
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of HINT1 mRNA in the tissue of malignant melanoma and nevocellular nevus. Methods Half-quantitative RT-PCR was used to measure the expression of HINT1/PKCI-1 mRNA in fresh and archival tissues of 25 patients with malignant melanoma and 25 patients with nevus. Results In the case of the same specimen, the expression of HINT/PKCI-1 mRNA showed no difference in the tissue treated with formalin fixation and paraffin embedment with that in the fresh tissue. The expression level of HINT/PKCI1 mRNA was 0.49 ? 0.04 in nevus and 0.31 ? 0.07 in malignant melanoma, and the difference was significant (P
