Study of the expression and correlation of PTTG and VEGF in human extrahepatic cholangiocarcinoma
- VernacularTitle:肝外胆管癌组织中PTTG和VEGF的表达及相关性研究
- Author:
Ling CHEN
;
Huihuan TANG
;
Chao FEN
- Publication Type:Journal Article
- Keywords:
Bile Duct Neoplasms/pathol;
Bile Duct,Extraheptic/pathol;
PTTG;
VEGF
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of the expressions of PTTG and VEGF proteins in extrahepatic cholangiocarcinoma,and study its role in the development of extrahepatic cholangiocarcinoma.Methods Expression of PTTG and VEGF proteins was detected by SABC immunohistochemical technique in 36 cases of extrahepatic cholangiocarcinoma,30 cases of adjacent histologically noncancerous bile duct tissues and 12 cases of benign bile duct lesions.Results The positive rates of PTTG and VEGF proteins were(72.2)%(26/36) and 83.3%(30/36) respectively,in extrahepatic cholangiocarcinoma;and 63.3%(19/30) and 76.7%(23/30) in adjacent histologically noncancerous bile duct tissues.The expression of PTTG protein was significantly positively correlated with that of VEGF protein(P
