Study on clinical significance of expression of p16,nm23 and PTEN gene in malignant tumors of biliary system
- VernacularTitle:胆系恶性肿瘤p16,PTEN和nm23基因的表达及其临床意义
- Author:
Ping CUI
;
Pin PU
;
Xiaoxia ZHAO
;
Tao WU
;
Shikun YANG
;
Zhupei HU
- Publication Type:Journal Article
- Keywords:
Bilary Tract Neoplasms/pathol;
Gene Expression;
Oncogene Proteins
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical significance of the gene protein expression of p16,nm23 and PTEN in bile duct carcinoma.Methods The expression of p16,PTEN and nm23 gene protein in tissues of 63 cases of malignant tumors of biliary system(33 cases of bile duct carcinoma,30 cases of carcinoma of gallbladder) and 20 cases of benign bile duct lesion were studied by SP immunohistochemical technique and analyzed together with clinicopathologic data.Results The positive expression of p16,PTEN and nm23 in bile duct carcinoma tissue was low to medium,their expression rate was 36.5%,38.1% and 23.8%,(respectively),and was significantly lower than that of bile duct benign lesions(P
