Study on reversal of mutidrug resistance of GBC-SD cell lines by grape seed polyphenols
- VernacularTitle:葡萄籽多酚逆转胆囊癌细胞株GBC-SD耐药的研究
- Author:
Fenghui YANG
;
Zhanmin WANG
;
Xinlin WU
- Publication Type:Journal Article
- Keywords:
Gallbladder Carcinoma Cell Line;
Grape Seed Polyphenols/pharm;
Mutidrug Resistance
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of reversal of mutidrug resistance of GBC-SD cell lines by grape seed polyphenols(GSP).Methods GBC-SD cell lines were used to determine the effect of GSP.MTT assay was adopted to evaluate the cytotoxity(IC_(50)),RT-PCR were used to determine MDR1mRNA,(P-gp),bcl-2 and cellular adriamycin was measured by flow cytometry.Results In non-toxic(3?g/mL) and low toxic(6?g/mL) comcentration of GSP treated group(P
