Relationship of hypoxia inducible factor 1? and vascular endothelial growth factor expression with angiogenesis in gastric carcinoma
- VernacularTitle:缺氧诱导因子1?及血管内皮生长因子的表达与胃癌血管生成的关系
- Author:
Yixue GU
;
Hanxian LI
;
Yin KAN
;
Hanqun WAN
;
Zhihan TANG
;
Tianshu GAO
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factors;
Stomach neoplasms;
Anoxia;
Capillaries
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of hypoxia inducible factor 1?(HIF-1?),vascular endothelial growth factor(VEGF) and micro vessel density(MVD) in gastric carcinoma and to explore their correlation with clinical pathological features such as cancer invasion and metastasis.Methods Forty-eight samples of gastric carcinoma tissues were examined for the expression of HIF-1?,VEGF and CD34 by immunohistochemical method.Results The positive expression rates of HIF-1? and VEGF were 66.7% and 60.4% in gastric carcinoma respectively.The mean value of MVD was 42.5?14.7 in gastric carcinoma.The expressions of HIF-1?,VEGF and the value of MVD were significantly correlated with the depth of invasion,lymph node metastasis and TNM stage.The HIF-1? expression was positively correlated with VEGF expression and MVD value.Conclusion The overexpression of HIF-1?,VEGF and MVD consist in gastric carcinoma tissue.The HIF-1? expression is positively correlated with VEGF expression and MVD value.The overexpression of HIF-1?,VEGF and MVD value are closely related with invasion,metastasis and poor biological behavior of gastric carcinoma.
