Experimental study on transplanted rectal tumor of mice treated by photodynamic therapy combined with 5-FU
- VernacularTitle:光动力联合5-FU治疗裸鼠直肠移植瘤的实验研究
- Author:
Xiaoping LI
;
Fan WANG
;
Junhua ZHANG
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
Photochemotherapy;
Fluorouracil
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effectiveness of photodynamic therapy(PDT) combined with 5-FU on the treatment of transplanted rectal tumor in mice.Methods The nuke mice transplanted tumor of human rectal cancer HR8348 cells were treated with PDT alone,5-Fu alone or PDT combined with 5-Fu respectively.The volume and weight of the tumors were measured and the histopathologic changes were studied.The level of malonaldehyde(MDA) in the tumors in different groups was analyzed.Results The lethal effect on transplanted rectal tumor was more obvious and the level of MDA was more higher in the PDT combined with 5-Fu group than those of other groups.Conclusion PDT combined with chemotherapy may serve as a method in treatment of tumor.
