The expression of HLA-DR and dendritic cells infiltration of endometrial carcinoma and their clinical significance
- VernacularTitle:子宫内膜癌HLA-DR表达与树突细胞浸润及其临床意义
- Author:
Zhansan SU
;
Jianbin ZHOU
;
Baoan LIU
;
Senlin CHEN
- Publication Type:Journal Article
- Keywords:
Endometrial neoplasms;
HLA-DR antigens;
Dendritic cells
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of HLA-DR and distribution of dendritic cells(DC) in endometrial carcinoma and to evaluate their influence on clinical staging and prognosis.Methods The 86 cases of patients with endometrial carcinomas were detected by immunohistochemical SP method for HLA-DR and S100 positive dendritic cells,and the predictive value in clinical stage and prognosis were analyzed.Results The positive rate of HLA-DR expression was 27.9%(24/86),which was decreased with the increase of clinical staging(P0.05).There were 46.5%(40/86) of the cases with a dense infiltrate(≥10/HPF) of S100 positive DC.There was significant difference on the density of DC infiltrating among the patients with different clinical stages and prognosis(all P
