The changes and significance of serum cytokine in rats with acute necrotizing pancreatitis
- VernacularTitle:急性坏死性胰腺炎大鼠血细胞因子含量的变化和意义
- Author:
Yuehua CHEN
;
Mingxing DING
;
Weihong XU
;
Yanping CHEN
;
Wei HUANG
- Publication Type:Journal Article
- Keywords:
Pancreatitis,acute necrotizing factor;
Tumor necrosis factor-alpha;
Interleukin-1;
Interleukin-6;
Interleukin-10
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes and significance of serum tumor necrosis factor-?(TNF-?),interleukin-1?(IL-1?),IL-6 and IL-10 in rats with acute necrotizing pancreatitis(ANP).Methods Sixty-four Wistar rats were randomly divided into 2 groups: sham operation group(SO group n=32) and ANP group(n=32).The ANP model was established by using retrograde injection of Sodium Taurocholate into cholangiopancreatic duct.The changes of serum endotoxin(ET),TNF-?,IL-1?,IL-6 and IL-10 in different groups and different time points were observed.Results The levels of serum ET,TNF-?,IL-1?,IL-6 and IL-10(except IL10 of ANP group in 16h) in rats of ANP group were significantly higher than those of SO group(P
