The effect of lysophosphatidyl choline on the expression of scavenger receptor class B type Ⅰ in L-20 cells and the impact of simvastatin
- VernacularTitle:溶血卵磷脂对L-20细胞SRBI表达的影响及辛伐他汀的干预作用
- Author:
Kaichao LONG
;
Ming SUN
;
Changjiang XIAO
;
Tong LI
- Publication Type:Journal Article
- Keywords:
Lysophosphatidylcholines;
Simvastatin;
Genes;
Hepatocytes;
Receptors,immunologic
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the impact of lysophosphatidyl choline(LPC) on the expression of scavenger receptor class B type Ⅰ(SRBI) in L-20 cells and the impact of simvastatin.Methods Cultured hepatocytes were randomly assigned to normal group,LPC-damaged group and simvastatin group.The changes of mRNA and protein expression of SRBI in hepatic tissue were assayed by RT-PCR,immunocytochemistry and Western blot,respectively.Results The expression of SRBI was higher in LPC-damaged hepatocytes than that in normal cells at both mRNA and protein level(P
