State and prevention of glucocorticoid - induced osteoporosis in patients with primary glomerulonephritis
- VernacularTitle:原发性肾脏病患者糖皮质激素性骨质疏松的发生及预防治疗情况
- Author:
Hang CHEN
;
Mei WANG
- Publication Type:Journal Article
- Keywords:
Primary glomerulonephritis;
Glucocorticoid-induced osteoporosis;
Bone mineral density
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the state of glucocorticoid(GC) - induced osteoporosis (GIOP) and the current prevention of GIOP in patients with primary glomerulonephritis. Methods Primary glomerulonephritis patients receiving GC therapy were observed and bone mineral density (BMD) in the lumbar spine and the femoral neck were measured. Age, sex, body - mass - index, smoking history, the time and accumulative dose of GC treatment, and the state of osteoporosis prevention were investigated, the factors that influence the BMD were analyzed. Results A total of one hundred and twenty- three patients were included in this study. Among them, osteoporosis and os-teopenia were found in 82 patients (66.7%). Lumbar spine BMD decrease gradually with the increase of the accumulative dose of GC. There were statistical differences in the BMD of lumbar spine in patients with receving GC at the period of less than 1 month compared with other groups( 1-12 months) (P
