Clinical significance of serum IL - 8, sICAM - 1 and sE - selectin in patients with chronic obstructive pulmonary disease
- VernacularTitle:COPD患者血清白细胞介素-8、可溶性细胞间黏附分子-1和可溶性E-选择素的测定及临床意义
- Author:
Gang HE
;
Jianying LIU
;
Guoying ZHONG
;
Qin LI
- Publication Type:Journal Article
- Keywords:
Obstructive lung diseases;
Airway inflammation;
IL-8;
sICAM-1;
sE-selectin
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the roles of IL-8, sICAM-1 and sE- selectin in the airway inflammation of chronic obstructive pulmonary disease (COPD). Methods The levels of IL - 8, sICAM -1 and sE-selectin in the serum were measured by double-sandwich ELISA in 40 COPD patients and 20 healthy persons. The COPD patients were divided into two groups: 20 cases in COPD a-cute exacerbation group and 20 cases in stable period group. Results The IL- 8, sICAM- 1 and sE - selectin level of serum in patients with COPD acute exacerbation group and stable period group were obviously higher than those in healthy group, and patients with COPD acute exacerbation group was obviously higher than those in stable period group (P
