Expression of interleukin -12 and correlation between interleukin -12 and eosinophils in nasal mucosa in allergic rhinitis mice
- VernacularTitle:变应性鼻炎动物模型白细胞介素12与嗜酸性粒细胞的变化
- Author:
Qiu DENG
;
Yun ZHOU
;
Jun YANG
;
Erzhong FAN
- Publication Type:Journal Article
- Keywords:
Rhinitis,Allergic,Perennial;
Interleukin -12;
Eosinophils;
Budesonide
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the expres-sion of interleukin-12 and eosinophils in the nasal mu-cosa of allergic rhinitis mice. METHODS Thirty nine male BALB/c mice,6～8 weeks old,were randomly divided into three groups: control group,allergic rhinitis (AR)group, and Budesonide treatment group. Al-lergic rhinitis model in mice were established by using ovalbumin intraperitoneal immunization and nasal anti-gen challenge. The nasal mucosa obtained from mice of three groups were stained routinely by HE and im-munohistochemical method to observe the distribu-tion and expression of interleukin-12 and eosinophils. RESULTS The expression of eosinophils in the nasal mucosa of AR group was significantly higher than con-trol group(P
