Analysis of circulating activated platelet and its significance in patients with cerebral infarction
- VernacularTitle:脑梗死患者循环活化血小板的检测及临床意义
- Author:
Zhixiang DING
;
Chunxiu YANG
;
Jianping QIN
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Platelet activation;
Receptors,fibrinogen;
P-selectin;
Flow cytometrg
- From:
International Journal of Laboratory Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the activation of circulating platelet in patients with cerebral infarction(CI) and its correlation with CI.Methods The fibrinogen receptor(FIB-R) and P-selectin were used as molecular marker of circulating platelets, which were analyzed by flow cytometry in 80 healthy persons and 127 CI patients in acute and rehabinating period.Results The FIB-R expression on circulating platelet of CI patients in dangerous period was significantly higher than that in steady period and healthy persons(P0.05).Conclusion The activation of circulating platelet has a close relationship with CI. FIB-R may be a sensitive molecular marker of circulating activated platelet. It will help to evaluate the severe extent of CI and give an anti-platelet treatment as soon as possible to improve the prognosis of CI through monitoring the FIB-R of CI patients successively.
