Serum Soluble CD40L Level and its Application in Coronary Heart Disease
- VernacularTitle:可溶性CD40L在冠心病患者血清中的检测意义
- Author:
He CHEN
;
Qixian WANG
;
Dongbo DENG
;
Yanxia ZHU
;
Qin FANG
- Publication Type:Journal Article
- Keywords:
Soluble CD40 ligand;
Coronary heart disease;
Atherosclerosis;
Angina pectoris
- From:
Journal of Kunming Medical University
1989;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum of soluble CD40 ligand(sCD40L) in coronary heart disease and its relationship with serum lipid levels and the extent of coronary stenosis,whether upregulation of CD40L system is related to stability of atherosclerotic plaque in patients with acute coronary syndrome.Methods Enzyme-linked immunosorbent assay(ELISA) was used to measure the level of sCD40L in 64 patients with coronary heart disease(18 with acute myocardial infarction,19 with unstable angina pectoris and the other 27 with stable angina pectoris) and 20 matched healthy controls.Coronary stenosis of 29 patients were assessed by angiographic coronary stenosis morphology.Results sCD40L level was significantly higher in patients with acute coronary syndrome(ACS)((19.8?3.0)、(19.6?4.3)ng/mL in acute myocardial infarction and unstable angina pectoris group,respectively)than that of those with stable coronary heart disease and that of controls((8.3?3.2)ng/mL and(2.6?1.9)ng/mL,respectively P
