In Vivo Tissues Distribution and Pharmacokinetics:Survey of2Kinds of Monostearin Solid Lipid Nanoparticle Preparations
- VernacularTitle:2种单硬脂酸甘油酯固体脂质纳米粒制剂的体内组织分布及药动学研究
- Author:
Bin SHEN
- Publication Type:Journal Article
- Keywords:
Monostearin;
Solid lipid nanoparticles;
PEG2000;
Tissue distribution;
Pharmacokinetics
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the tissues distribution of monostearin solid lipid nanoparticles(MSLN)and MSLN(PEG-MSLN)that had been modified by PEG2000in vivo of mice and the pharmacokinetics in vivo of rats,and to investigate the influence of PEG2000modification on MSLN tissues distribution and pharmacokinetics.METHODS:MSLN was prepared by a novel solvent diffusion method.The particle diameters and Zeta potentials of MSLN were determined.Tissues distribu?tions and pharmacokinetics of2kinds of MSLN preparations in vivo of rats after vena caudalis administration were determined and the determining results were calculated with rhodamine B as fluorescent marker.RESULTS:2kinds of MSLN preparations showed a similar particle diameter distribution with Zeta potential of MSLN at—20mV.MSLN targeted to liver after vena caudalis intravenous injection and the general circulation of nanoparticles was significantly prolonged to2.2times after modified by PEG2000.CONCLUSION:MSLN can amelioration systemic circulation after modification with PEG2000and which can be used as liver-targeted drug carrier.
