Behavioral Study on Osmotic Releasing of Acyclovir Eye-gels in Isolated Cornea of Rabbits
- VernacularTitle:阿昔洛韦眼用凝胶在兔离体角膜中的渗透释药行为研究
- Author:
Rongzhi LU
- Publication Type:Journal Article
- Keywords:
Aciclovir;
Eye-gels;
HPLC;
Isolated cornea;
Osmotic releasing
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the osmotic releasing of acyclovir in isolated cornea of rabbits.METHODS:The cu?mulative osmotic drug releasing amount of acyclovir eye-gels and acyclovir eye-drops in the isolated corneal of rabbits were determined by HPLC with glutathion buffer as releasing medium.Meanwhile the curves of drug releasing were drawn.RE?SULTS:The osmotic drug releasing of acyclovir eye-gels conformed to the first-order kinetics equation.The cumulative osmotic drug releasing amount of acyclovir eye-drops was higher than that of eye-gels at0.25h;however,it worked in re?verse thereafter.CONCLUSION:Within a short time after administration(0.25h),aqua oculi drug concentration of acyclovir eye-drops was higher than that of acyclovir eye-gels,while the retention time of eye-gels was longer and cornea serves as drug reservoir to some degree.
