Research on Protection of Xinnaoshenkang(XNSK)on Renal Ischemical Reperfusion Injury Model Rats
- VernacularTitle:心脑肾康对肾缺血再灌注损伤模型大鼠的保护作用研究
- Author:
Jie JIAN
;
Qing XU
- Publication Type:Journal Article
- Keywords:
Xinnaoshenkang;
Renal ischemical reperfusion injury;
Rat;
Protection
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the protection of XNSK on renal ischemical reperfusion injury model rats.METHODS:A total of60rats were randomized into sham operation group(without occlusion of renal arteries of both kidneys and admin?istered with0.1%dimethyl sulfoxide normal saline),control group(0.1%dimethyl sulfoxide normal saline),positive control group(administered with Shenfukang capsules)and XNSK(high,medium and low dose subgroups)group.Levels of serum creatinine(Scr),urea nitrogen(BUN)and malonaldehyde(MDA)in renal tissue,hemocuprein(SOD),active oxygen(ROS)and nitrogen monoxidum(NO)were determined respectively meanwhile the pathomorphology changes of tissues were observed.RESULTS:As compared with the control group,levels of Scr,BUN,MDA,ROS and NO in all the3(high,medium and low doses)XNSK subgroups(which were administered with drugs for7days before operation and undergone reperfusion once after operation)had a reduction while SOD level had an increase.And there was a mitigated pathomorphology change in nephridial tissues(P
