Identification and Determination of Illegal Adding of Glibenclamide in Traditional Chinese Medicine for Health Care
- VernacularTitle:中药保健品中非法掺入格列本脲的检测
- Author:
Zhengzheng XIA
;
Qi FAN
- Publication Type:Journal Article
- Keywords:
Traditional Chinese medicine for health care;
Qiaoqi capsule;
Glibenclamide;
TLC;
HPLC;
MS
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for identification and determination of illegal adding of chemical substance glibenclamide in traditional Chinese medicine(TCM)for health care,and to provide the reference for the governmental de?partment of drug surveillance and drug inspection.METHODS:TLC and HPLC were employed to isolate and analyze the ex?tract from Qiaoqi capsule suspected of illegal addition of glibenclamide.Glibenclamide was identified by HPLC-DAD spec?trography and ESI-MS technology,and the content determination was made by HPLC.RESULTS:Both capsule sample A and B were detected to contain glibenclamide,the concentrations of which were1.51mg per capsule and0.55mg per capsule respectively.CONCLUSION:The established method is specific,sensitive,and convenient,and can be used efficiently for con?trol and surveillance of illegal adding of chemical substance glibenclamide in TCM for health care.
