An experimental study on substance P in plasma, laryngopharygeal tissue and the lungs in guinea pigs with anaphylactic shock
- VernacularTitle:过敏性休克豚鼠血浆咽喉肺组织中P物质的观测
- Author:
Jiwei BAI
;
Cairong GAO
;
Guangmu REN
- Publication Type:Journal Article
- Keywords:
Forensic pathology;
Anaphylactic shock;
Substance P;
Guinea pig;
Immunohistochenustry
- From:
Chinese Journal of Forensic Medicine
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pathognomonic findings of anaphylactic shock in forensic medicine. Methods Animal model of anaphylactic shock was developed in guinea pigs. Substance P level in plasma was determined radioimmunoassay, and detected in laryngopharyneal tissue and the lungs by immunohistochemical SABC method followed by image analysis using BI - 2000 image analyzing system. Positive index (PI) was calculated. Results There was a statistically significant difference for substance P concentration in plasma between the guinea pigs with anaphylactic shock (131.01? 18.93pg/?l)and the control animals (87.70 ?7. 60pg/?l) (P
