Change of cytokine expression in normal pregnancy and the puerperium.
- Author:
Kye Hyun KIM
1
;
Hyeong Ok KIM
Author Information
1. Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. khmd.kim@samsung.com
- Publication Type:Original Article
- Keywords:
Cytokine;
Pregnancy;
Puerperium
- MeSH:
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Interleukin-2;
Interleukin-4;
Interleukin-6;
Plasma;
Postpartum Period;
Pregnancy;
Pregnancy Trimester, Second;
Transforming Growth Factor beta;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Perinatology
2008;19(4):351-355
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the serial relationship of cytokine production during normal pregnancy and in the puerperium. METHODS: Plasma cytokine (TNF-alpha, INF-gamma, IL-2, TGF-beta, IL-4, and IL-6) levels were determined by enzyme-linked immunosorbent assay (ELISA) in 90 healthy gravidas during the second trimester and 6 weeks postpartum. RESULTS: TNF-alpha, INF-gamma, and TGF-beta levels increased significantly after delivery (p<0.05). Although IL-2, IL-4, and IL-6 had a tendency to increase after delivery, the change was not significant. CONCLUSION: There was a decrease in cytokine levels during pregnancy when compared to puerperium. In particular, TNF-alpha, INF-gamma, and TGF-beta were inversely related to the maintenance of normal pregnancy.
