The inhibition of heme oxygenase-1 on experimental abdominal aortic aneurysm
- VernacularTitle:氯血红素对腹主动脉瘤形成的抑制作用的实验研究
- Author:
Yan CHE
;
Qiang ZHANG
;
Dayong LI
;
Yong YANG
;
Chenglin SUN
;
Shijie XIN
- Publication Type:Journal Article
- Keywords:
Aortic aneurysm, abdominal;
Oxygenases;
Animals, laboratory
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of heme oxygenase-1 (HO-1) gene expression on murine experimental abdominal aortic aneurysm (AAA).Methods Wistar rats were divided into hemin (experimental group) and saline (control group) group randomly, and experimental AAA model was established by elastase perfusion. The specimen was obtained at postoperative day 7, and the dilatation rate was calculated. In situ hybridization was applied to detect the expression of HO-1 mRNA in aortic wall, while immunohistochemical staining was used to detect the protein expression of ICAM-1 and HO-1. Results In experimental group, the aorta dilation was inhibited and aneurysm was not observed. In experimental group, HO-1 mRNA and protein expression was strengthened (P
