The expression of hypoxia-inducible factor-la and related genes in ruptured abdominal aorta aneurysm
- VernacularTitle:缺氧诱导因子-1?及相关基因在破裂性腹主动脉瘤中的表达及意义
- Author:
Jun YANG
;
Xinhua HU
;
Chengwei LIU
;
Zhishen ZHANG
;
Dehua YANG
;
Qiang ZHANG
- Publication Type:Journal Article
- Keywords:
Aneurysm, ruptured;
Genes;
Hypoxia-inducible factor-1?
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of hypoxia-inducible factor(HIF)-1? and related genes in ruptured abdominal aorta aneurysm(RAAA) and explore the underlying pathogenesis. Methods 18 RAAA specimens were collected and 20 AAA tissues were used as control. Total RNA was extracted and Northern blot was used to evaluate the expression of HIF-1? mRNA. Western blot and immunohistochemistry method were used to determine the expression of HIF-1? and vascular endothelial growth factor(VEGF). Microvessel density(MVD) was measured for CD34. Results The expression of HIF-la mRNA was significantly higher in RAAA than that in AAA (P
