Correlation of Membrane Glycoprotein PC-1 Gene Polymorphism with Type 2 Diabetes Mellitus and Insulin Resistance
- VernacularTitle:PC-1基因多态性与2型糖尿病及胰岛素抵抗的相关性
- Author:
Maoling LIU
;
Shaoting WU
;
Zuxun LU
- Publication Type:Journal Article
- Keywords:
Membrane glycoprotein;
Gene polymorphism;
Type 2 diabetes mellitus;
Insulin resistance
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of the K121Q polymorphism of membrane glycoprotein PC-1 gene with the features of insulin resistance(IR) and type 2 diabetes mellitus(T2DM).Methods The K121Q polymorphism in exon 4 of PC-1 gene were determined with the technique of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) in 133 patients with T2DM and 108 controls with normal glucose tolerance(NGT) in Shenzhen city.The clinical and laboratory data were also compared between type 2 diabetic patients with different genotypes.Results No statistically significant differences were observed in the genotype and allele frequencies between the control and the T2DM subjects.The concentrations of fasting plasma glucose(FPG),triglycerides(TG) and C-peptide were higher in T2DM patients with KQ genotype than with KK genotype(P
