Analysis of the Autoantibodies against AT1 Receptor and ?1 Receptor in Chronic Glomerulonephritis with Renal Failure
- VernacularTitle:慢性肾小球肾炎伴肾衰患者血清?_1肾上腺素受体和抗血管紧张素Ⅱ受体1型自身抗体检测结果分析
- Author:
Linshuang ZHAO
;
Yuhua LIAO
;
Min WANG
- Publication Type:Journal Article
- Keywords:
Chronic glomerulonephritis;
Receptors;
Autoantibodies
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of the autoantibodies against angiotensin Ⅱtype 1 receptor(AT1-receptor) and ?1-adrenergic receptor(?1-receptor)in the development of chronic glomerulonephritis(CGN) with renal failure.Methods The epitopes of the second extracellular loop of AT1 receptor(165-191),?1 receptor(192-21),M2 receptor(169-191) were synthesized and used respectively to screen sera autoantibodies from patients with chronic renal failure(n=66),hypertension without renal failure(n=58) and healthy blood donors(n=40,control) by ELISA.Results In patients of chronic glomerulonephritis with renal failure,the positive rates of the autoantibodies against AT1-receptor and ?1-receptor were 56.1% and 53.0% respectively.The positive rates were all higher than those in patients of the hypertension without renal failure(the positive rates were 15.5% and 12.1%,respectively) and in the healthy donors(10% and 12.5%,respectively)(P
