Immunohistochemistry research of interface membrane around loosening hip prosthesis
- VernacularTitle:松动人工髋关节界膜的免疫组化研究
- Author:
Weijie LU
;
Weiming LIAO
;
Nansheng YU
;
Xinyue LUO
;
Bo BAI
;
Zhixiong LIN
;
Yingying GU
;
Muchang LIU
;
Tong YANG
- Publication Type:Journal Article
- Keywords:
Hip;
Loosening;
Interface membrane;
Immunohistochemistry
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Collecting the loosening periprosthetic interface-membrane, to discuss the mechanism of hip arthroplasty loosening. Methods The periprosthetic interface tissues of 29 hip arthroplasty revision cases from February 1995 to December 2003 were collected. The retrieved periprosthetic interface tissues were detected by immunohistochemistry. Some of them were studied by electronic microscope. Results (1)Transmission electronic microscope examination: the mitochondria swell. There were some substantia like lipid in the plasm of macrophages. Wear particles could be seen under scaning electronic microscope.(2)Immunohistochemistry: there were 22 IL-1? positive cases in cells of interface membrane. There were 29 IL-6 positive cases in cells of interface membrane. There were no positive results in TNF-? test. Conclusion (1)The wear particles of arthroplasty are important factors which cause biological reaction.(2)The interface membranes contain cytokine IL-1? and IL-6, which may play an important role in periprosthetic osteolysis and arthroplasty loosening.
