Effect of glycine on changes of TNF-?, IL-1?, IL-6, IL-8 and IL-10 in rat serum and pancreas tissue with acute necrotizing pancreatitis
- VernacularTitle:甘氨酸对急性坏死性胰腺炎鼠血和胰腺组织中TNF-?、IL-1?、IL-6、IL-8和IL-10的影响
- Author:
Haijun LI
;
Shuyou PENG
;
Yingbin LIU
;
Jiangtao LI
;
Bin XU
;
Jianwei WANG
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Glycine;
Tumor necrotic factor;
Interleukin-1;
Interleukin-6;
Interleukin-8;
Interleukin-10
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the effect of glycine on the changes of TNF-?, IL-1?, IL-6, IL-8 and IL-10 in rat serum and pancreas tissue with acute necrotizing pancreatitis (ANP). METHODS: 150 Wistar rats were randomly divided into sham operation group (SO), ANP group and ANP+glycine group (ANP+Gly). The ANP model was established by retrograde injection of sodium taurocholate into cholangiopancreatic duct. The glycine (1 g/kg) was injected intravenously 10 min before sodium taurocholate injection. The changes of ET, TNF-?, IL-1?, IL-6, IL-8 and IL-10 in serum and pancreas tissue were determined and the pathological study was performed as well. RESULTS: The levels of ET, TNF-?, IL-1?, IL-6, IL-8 and IL-10 in serum and pancreas tissue (except IL-10 at 0 h and 12 h in ANP group) in ANP and ANP+Gly groups were significantly higher than those in SO (except at 0 h) (P
