Expression of Ca~(2+)-activated Cl~- channel gob-5 and mucin gene Muc5ac in lungs of asthmatic mice
- VernacularTitle:钙激活的氯通道gob-5和粘蛋白基因Muc5ac在小鼠哮喘模型肺部的表达
- Author:
Jianbo LIU
;
Zhenxiang ZHANG
;
Yongjian XU
;
Lihua XING
;
Huilan ZHANG
- Publication Type:Journal Article
- Keywords:
Asthma;
Chloride channels;
Protein Muc5ac;
Mucins
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the changes of a member of Ca~ 2+ -activated Cl~- channel, gob-5 and mucin gene Muc5ac expression in lungs of asthmatic mice. METHODS: Twenty-two pathogen-free BALB/c mice were randomly divided into asthma group and control group. Expression of gob-5 mRNA and Muc5ac protein in lungs were detected by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical assay, respectively. RESULTS: The expression of gob-5 mRNA in asthma group was positive (0.2297?0.0186,A), whereas in control group was absent (P
