Effect of lipid infusion on plasma resistin and ghrelin levels in rats
- VernacularTitle:脂质灌注对大鼠血浆抵抗素和ghrelin的影响
- Author:
Ling LI
;
Gangyi YANG
;
Rong LI
;
Ke LI
;
Yi TANG
- Publication Type:Journal Article
- Keywords:
Ghrelin;
Resistin;
Insulin resistance;
Lipids
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of lipid-induced insulin resistance on plasma resistin and ghrelin levels in awake rats. METHODS: A hyperinsulinaemic-euglycaemic clamp was established in awake chronically catheterized rats. Two groups of rats were studied either with a 4 h intraarterial infusion of lipid/heparin or saline. Insulin-mediated peripheral and hepatic glucose metabolism was assessed by insulin clamp combined with [~3H]-glucose infusion, and plasma resistin and ghrelin concentrations were examined before and after clamp with ELISA. RESULTS: During clamp, there was a significant increase in plasma free fatty acid (FFA, P
