Expression of survivin in pancreas in streptozotocin-induced diabetic mice
- VernacularTitle:实时FQ-PCR检测链脲佐菌素诱导糖尿病小鼠模型胰腺survivin基因的表达
- Author:
Mingtong XU
;
Hua CHENG
;
Lihong CHEN
;
Zhaofan LUO
;
Wenfeng XIE
;
Li YAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Streptozocin;
Genes, survivin;
Pancreas
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of survivin in pancreas in the streptozotocin-induced diabetic mice. METHODS: Low dose of streptozotocin was used to induce diabetes mellitus in BALB/c mice. Body weight and blood glucose concentrations were examined at 1, 2, 3 and 4 weeks after the streptozotocin injection. Expression of survivin mRNA was detected by real-time FQ-PCR. RESULTS: Survivin was expressed in the pancreas of normal BALB/c mice. Low dose of streptozotocin provoked hyperglycaemia with increased survivin expression in the pancreas, but blood glucose concentration and expression of survivin was not significantly changed in control group. CONCLUSION: Survivin is expressed in the pancreas of normal BALB/c mice. Streptozotocin increases survivin expression in the pancreas, which may be related with islets regeneration.
