Significance of expression of thrombospondin-1 and receptor-CD36 in hepatocellular carcinoma
- VernacularTitle:血小板反应蛋白-1及受体CD36在肝细胞性肝癌中的表达及意义
- Author:
Jianfeng XUE
;
Zhigang PANG
;
Chao LIU
;
Guangtian WANG
;
Fubao LIU
;
Shuyou PENG
- Publication Type:Journal Article
- Keywords:
Thrombospondin 1;
Angiogenesis, pathologic;
Liver neoplasms
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the expression of thrombospondin-1 (TSP-1) and receptor-CD36, and investigate the relationship between tumor invasive capability and microvessel density and thrombospondin-1. METHODS: 43 hepatocellular carcinoma (HCC) cases were under investigation. Tissues from tumor, corresponding adjacent non-HCC tissue were stained with CD34 to show the MVD. TSP-1 and CD36 were examined by immunohistochemistry (SP) and RT-PCR. Relationship between clinical pathological features and above parameters was analyed. RESULTS: The staining of TSP-1 in HCC tissue is significantly lower than that in corresponding adjacent non-HCC tissue. Expression of TSP-1 was correlated to tumor thrombi, capsule, tumor invasive capability and CD36. CD36 was also correlated to tumor thrombi and tumor invasive capability. MVD was significantly higher in TSP-1, CD36 positive group than that in negative group. CONCLUSION: TSP-1 inhibits the growth, invasion and angiogenesis in HCC. TSP-1 may take effect through CD36.
