Serum Pharmacochemistry Changes of Guan Xin Ⅱ Oral Decoction in Healthy Volunteers
- VernacularTitle:健康志愿者口服冠心Ⅱ号煎剂后血清中药物化学成分变化研究
- Author:
Hongquan GAN
;
Qibing MEI
- Publication Type:Journal Article
- Keywords:
Compound traditional Chinese medicine;
Guan Xin Ⅱ;
Decoction;
Serum pharmacochemistry;
High performance liquid phase finger print
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the presence of the chemical compositions of Guan XinⅡ(GXEH)oral decoction in human serum.METHODS:The analysis of finger prints of the medicated serum sample obtained from the volunteers treated with GXEH decoction was conducted with3different pretreatment procedures and2different HPLC methods,and which were compared with decoction.RESULTS:The numbers of the discrepant chromatographic peaks detected from the decoction and the medicated serum were respectively less than30and10,danshensu,protocatechuic aldehyde,ligustrazine,paeoniflorin were failed to be traced in the latter.CONCLUSION:The numbers of chemical compositions of the compound preparation that can be traced in serum were limited and the active components that entered into body may be relatively limited in numbers.After oral administration of compound preparation,a part of chemical compositions of which may not presented as its original form in serum.
