Dynamic Changes of Serum TNF-?/IL-10 in Model Rats with Acute Necrotizing Pancreatitis and Study on the Intervention of Salvia Miltiorrhiza
- VernacularTitle:急性坏死性胰腺炎模型大鼠血清TNF-?/IL-10的动态变化及丹参的干预效应研究
- Author:
Shengchun DANG
;
Jianxin ZHANG
;
Jianguo QU
;
Xuqing WANG
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
TNF-?;
IL-10;
Salvia miltiorrhiza
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the dynamic changes of TNF-?/IL-10in model rats with acute necrotizing pancreatitis (ANP)and to study the intervention outcome of salvia miltiorrhiza.METHODS:A total of96rats were randomly divided into three groups(each with32rats):pancreatitis(P)group,salvia miltiorrhiza treatment(T)group and control group(C),the blood samples of rats in each group were taken to determine levels of TNF-?and IL-10and the ratio changes of TNF-?/IL-10.Meanwhile,pancreas tissue sample was collected for pathological scoring.RESULTS:Group P had significantly higher serum levels of TNF-?and IL-10than did group C(P
