Effects of Different Concentrations of Tween-80 on Dissolution of Ipriflavone Capsules
- VernacularTitle:吐温-80不同浓度对依普黄酮胶囊溶出度的影响
- Author:
Haitao ZHU
;
Liangyong HUANG
;
Jiyan CHEN
;
Zhenfen WANG
- Publication Type:Journal Article
- Keywords:
Ipriflavone;
Tween-80;
Dissolution;
Ultraviolet spectrophotometry
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of tween-80at different concentrations on the dissolution of ipriflavone capsules.METHODS:Different concentrations of tween-80ipriflavone capsules were prepared with contents and dissolutions of ipriflavone capsules determined by UV spectrophotometry,parameter values of T d ,T 50 and m were calculated and compared among each other.RESULTS:When tween-80were at a concentration range of1%～3%,the T 50 and T d diminished with the increase of concentration of tween-80,its optimal concentration was2.5%.CONCLUSION:The dissolution of ipriflavone capsules can be markedly increased if the preparation was added with optimal amount of tween-80(P
