The expression of VEGF-C and MMP-7 in gastric carcinoma and their correlation with tumor invasion and metastasis
- VernacularTitle:VEGF-C和MMP-7的表达与胃癌侵袭转移的关系
- Author:
Shikai HONG
;
Shaosen LI
;
Yunfei LU
;
Jinling LIN
;
Qinghua LIAO
;
Jian LIN
;
Yuan HUANG
;
Jian ZENG
- Publication Type:Journal Article
- Keywords:
Stomach Neoplasms/pathol;
Neoplasms Invasiveness;
Vascular Endothelial Growth Factor-C;
Matrix Metalloproteinase-7
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of vascular endothelial growth factor-C(VEGF-C) and matrix metalloproteinase-7(MMP-7) in gastric carcinoma and their correlation with tumor invasion and(metastasis).Methods Streptavidin peroxidase immunohistochemistry technique(SP)was used to detect the(expression) of VEGF-C and MMP-7 in 60 gastric carcinoma specimens,60 specimens of gastric mucosa(adjacent) to carcinoma,and 30 regional lymph node specimens.Results The positive expression rate of VEGF-C,MMP-7 in gastric carcinoma was markedly higher than that in normal gastric mucosa and gastric mucosa adjacent to carcinoma.The positive expression rates of VEGF-C and MMP-7 in metastatic regional lymph nodes were significantly higher than that in non-metastatic regional lymph nodes(P
