Effects of captopril on reperfusion arrhythmias in the atherosclerotic rabbits
- VernacularTitle:卡托普利对动脉粥样硬化兔心脏再灌注性心律失常的影响
- Author:
Mingsong HU
;
Jianguo HU
;
Jinfu YANG
;
Xinmin ZHOU
;
Yifeng YANG
- Publication Type:Journal Article
- Keywords:
Captopril;
Arteriosclerosis;
Myocardial reperfusion injury;
Arrhythmia;
Endothelins;
Malondialdehyde;
Nitric oxide
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of captopril on reperfusion arrhythmias in atherosclerotic rabbits.Methods A total of 32 New Zealand white rabbits were randomly divided into the control group,cholesterol food group(CF group) and captopril plus cholesterol food group(Cap group).The levels of endothelin(ET),malonaldehyde(MDA) and the content of nitric oxide(NO) were measured in different stage.The duration of ventricular tachycardia and the incidence of ventricular premature beats in 30 minutes after reperfusion were detected.Results The levels of ET and MDA were significantly decreased and the content of NO were significantly increased in the Cap group compared with that of the CF group.The average duration of ventricular tachycardia and the incidence of ventricular premature beats in 30 minutes after reperfusion were significantly reduced in the Cap group compared with the CF group.Conclusion The incidence of arrhythmias induced by the ischemia reperfusion injury may be decreased with the treatment of captopril in the atherosclerotic rabbits.
