Expression and clinical significance of IL-12 in acute cardiac allograft rejection in rats
- VernacularTitle:白细胞介素12在大鼠颈部心脏移植排斥反应中的表达及意义
- Author:
Jinping ZHAO
;
Ping LI
;
Sihai GAO
- Publication Type:Journal Article
- Keywords:
Interleukin-12;
Heart transplantation;
Graft rejection
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and clinical significance of IL-12 in acute cardiac allograft rejection in rats.Methods Two groups of SD rats received cervical heterotopic heart transplantation from allogeneic Wistar or syngeneic SD rats.The cardiac grafts were harvested at 1,3,5,and 7 days after transplantation and detected for the expression of IL-12 mRNA by reverse transcriptional polymerase chain reaction(RT-PCR).Results With the posttransplantation day delayed,the expression of IL-12 mRNA was significantly increased in allogeneic transplant group(P
